Drugs used in GOUT

DRUGS USED IN GOUT

Gout It is a metabolic disorder characterized by

hyperuricaemia (normal plasma urate 1–4 mg/

dl). Uric acid, a product of purine metabolism,

has low water solubility, especially at low pH.

When blood levels are high, it precipitates and

deposits in joints, kidney and subcutaneous tissue (tophy).

Secondary hyperuricaemia occurs in:

(a) Leukaemias, lymphomas, polycythaemia—

especially when treated with chemotherapy or

radiation: due to enhanced nucleic acid meta-

bolism and uric acid production.

(b) Drug induced—thiazides, furosemide, pyra-

zinamide, ethambutol, levodopa, clofibrate

reduce uric acid excretion by kidney.

Drugs used in gout are:

For acute gout

NSAIDs

Colchicine

Corticosteroids

For chronic gout / hyperuricaemia

Uricosurics Synthesis inhibitor

Probenecid Allopurinol

Sulfinpyrazone