Ketorolac

PYRROLO-PYRROLE DERIVATIVE

Ketorolac is a novel NSAID with potent analgesic and modest antiinflammatory activity. 

In postoperative pain it has equalled the efficacy of morphine, but does not interact with opioid receptors and is free of opioid consequences.

Here is the other NSAIDs, it may inhibits PG synthesis and relieves pain by a peripheral mechanism. In short-term pain, it has compared favourably with aspirin.

Ketorolac may rapidly absorb after oral and
i.m. administration. It has highly plasma protein bound and 60% excreted unchanged in urine.

Major metabolic pathway is glucuronidation;
It has plasma t½ is 5–7 hours.

Adverse Effects

Nausea, stomach pain, dyspepsia, ulceration, loose stools, drowsiness, headache, dizziness, nervousness, pruritus, pain at injection site, rise in serum transaminase and fluid retention can seen.

Ketorolac has uses concurrently with
morphine. However, it shouldn't be given to patients on anticoagulants.

Uses of Ketorolac

• Ketorolac is frequently uses in postoperative, dental and acute musculoskeletal pain: 15–30 mg i.m. or i.v. every 4–6 hours (max. 90 mg/day).

• It may even used for renal colic, migraine and pain due to bony metastasis.
• Orally it is use in a dose of 10–20 mg 6 hourly for short-term management of moderate pain.

• Ketorolac has been rated superior to aspirin (650mg), paracetamol (600 mg) and equivalent to ibuprofen (400 mg).

Remember

• Regular use for more than 5 days is not recommended.

• It should not use for preanaesthetic medication or for obstetric analgesia.
• KETOROL, ZOROVON, KETANOV, TOROLAC 10 mgtab, 30 mg in 1 ml amp.

• KETLUR, ACULAR 0.5% eye drops; 1–2 drops 2–4 times a day for noninfective ocular inflammatory conditions.