Abbreviations
CL- Clearance
k0- Intravenous infusion rate
CSS- Steady-state concentration
D- Dose
τ- Dosage interval
F- Fraction of drug absorbed into the systemic circulation
Q- Blood flow
E- Extraction ratio
f- Fraction of drug in the blood that is unbound
CLint- Intrinsic clearance
Css,u Steady-state concentration of unbound drug
VD- Volume of distribution
LD- Loading dose
MD- Maintenance dose
T1/2- Half-life
k- Elimination rate constant
ka- Absorption rate constant
α- Distribution rate constant
β- Terminal rate constant
t′- Postinfusion time
T- Duration of infusion
AUC- Area under serum- or blood- concentration-versus-time curve
Vmax- Maximum rate of drug metabolism
Km- Serum concentration at which the rate of metabolism equals Vmax /2
Cmax- Maximum serum or blood concentration
Cmin- Minimum serum or blood concentration
DR- Dosage rate
P-gp- P-glycoprotein
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